Principal Scientist - Computational Science, Non-Clinical Safety

Job description

Site Name: UK - Hertfordshire - Stevenage
Posted Date: Apr 23 2024

Principal Scientist - Computational Science, Non-Clinical Safety

The R&D Non-Clinical Safety (NCS) organisation has a focus on the application of cellular and molecular approaches to elucidate mechanisms of toxicity, understanding species differences, and identifying novel translational safety biomarkers to inform on project decisions.

The NCS organisation requires modelling and data science expertise (i.e., analysis of multi-dimensional data sets including flow cytometry and in vitro cellular imaging studies) to assist with the establishment of leading NCS platforms to evaluate the safety of new medicines.

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

In this role you will

• Design and develop computational methods for the analysis of high throughput, multi-dimensional data sets within NCS, with a focus on supporting multiparametric flow cytometry and in vitro cellular imaging studies.
• Support analyses of data sets including RNAseq, metabolomics, multiparametric cytokine data as NCS priorities require, with a particular focus on non-clinical safety and translational biomarkers.
• Identify and implement state-of-the-art data mining methodologies and machine learning algorithms to assist in the interpretation of cellular and molecular assay outcomes.
• Define, refine, and implement standards for quality control (QC) and quality assurance (QA) of methods choice to ensure data and reports are of high quality and build confidence in GSK's integrity and scientific credibility with internal partners and global regulatory authorities.
• Work collaboratively, establish and maintain close working relationships with R&D data scientists and NCS biological scientists generating data as part of a cross-functional team, contribute to the experimental design based on the objectives set for the study, and support customised data visualisation and analysis solutions.
• Translate informatics solutions into business-oriented biomedical understanding, to ultimately support decision-making endpoints in drug discovery and development processes.
• Execute and optimise analytic algorithms and data flow at scale, employing GSK's computing infrastructure.
• Produce high quality written documentation of methodologies applied (e.g. protocol contributions, scope of work), analysis results and interpretation for internal decision making purposes and inclusion in regulatory submissions as required.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• PhD relevant in Computational Biology (e.g., ADME, Biochemistry, Pharmacology, Toxicology, Mathematics, Bioinformatics). Proven mathematical expertise in one or more aspects relevant to non-clinical safety / toxicology is desirable
• Experience in analysing multi-dimensional data sets including flow cytometry and cellular imaging studies
• Experience in applying bioinformatics approaches to analyse and integrate 'omics data to enhance understanding of biological processes
• Ability to work collaboratively in a multidisciplinary environment with good communication skills
• Expertise in scientific computing and programming - such as R, Python

Closing Date for Applications - May 7th, 2024 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together.

Find out more:

Our approach to R&D .

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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