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Job description

The Immuno-Epigenetics (IE) team within the Epigenetics Research Unit (RU) is seeking a highly motivated scientist with experience in immunology and epigenetics to join the biology group in Stevenage (UK). The successful candidate will design and deliver work packages to support the validation of novel targets and the progression of on-going drug discovery programmes within our IE portfolio.

With strong experience in immunology, you will be responsible for developing novel, robust, in vitro cell-based immunology assays that recapitulate disease-relevant biology for compound testing and for exploring their mechanism of action in relevant cells. This is an exciting lab-based role that will allow the successful candidate to make a critical contribution to our efforts to develop therapeutics in the areas of immuno-inflammation and immuno-oncology at GSK.

You will need to be a creative, innovative self-starter, with excellent verbal and written communication skills, with a desire to lead from the lab. You will be accountable for generating high quality, robust data and must have the ability to work effectively both independently and as part of a multi-disciplinary matrix team. Additionally, you will need to be proactive and open to the ideas of others while having a deep curiosity and enthusiasm for learning novel approaches and techniques.

Your responsibilities will include:

• Development and implementation of cellular phenotypic and molecular assays for the evaluation of epigenetics drugs in the context of the immune response. This will include the use of multiple-parameter flow cytometry and other cell-based assay techniques.
• Execution of phenotypic screens to support Lead Optimisation programmes.
• Investigation of the mechanism of action of epigenetic inhibitors using gene expression techniques.
• Hands-on work in the area of chromatin molecular biology, including ChIP experiments.
• Representing the RU in project teams and providing biological experimental leadership in a particular area of research.

You will also be given the opportunity to represent the RU and Company by attending relevant meetings and by authoring publications in peer-reviewed journals.
Please ensure you apply before 24th of June 2019 to ensure you're in the running!

(Please take a personal copy of the Job Description, as this will not be available online post closure)

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.
If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

Why You?Basic qualifications:
• BSc and relevant experience in cellular and molecular biology
• Relevant experience in cellular immunology.
• Demonstrated practical laboratory experience gained from working in industrial or academic research environments.
• Significant expertise in cell culture techniques (isolation and culture of primary human cells) and in optimisation and execution of cell-based assays (phenotypic and mechanistic) to support pharmacological evaluation of compounds.
• Expertise in molecular biology techniques (RNA isolation, RT-PCR analysis)
• Hands-on experience in multi-parameter flow cytometric techniques for the study of cellular responses.
• Fluent spoken /written English.

Preferred qualifications:
• PhD in immunology, pharmacology or biology.
• Significant previous research experience working in pharma industry to support drug discovery programmes.
• Hands-on experimental experience in chromatin Biology techniques such as ChIP will be a plus.
• Experience in bioinformatic analysis of large data sets such as those from next generation sequencing experiments would be an advantage.

Why GSK?:
GSK is a science-led, global healthcare company that produces innovative medicines, vaccines and consumer healthcare products.
We are committed to overcoming some of the biggest challenges in global health; delivering products of value in a responsible, sustainable way; and providing access to medicine for the world's poorest communities

Contact information:
You may apply for this position online by selecting the Apply now button.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

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