Research Associate (Crossley Group) (Fixed Term)

Job description

The Crossley Lab at the world-leading CRUK Cambridge Institute is recruiting an enthusiastic and collaborative Postdoctoral Researcher to help uncover the mechanisms by which RNA-DNA hybrids contribute to human disease and how these pathways can be exploited for cancer diagnosis and treatment.

This is an exciting opportunity to join the group at a formative stage, supported by long-term funding from Cancer Research UK and the Wellcome Trust, and to shape a research programme aligned with your expertise and interests.

Research Opportunities

Projects within the lab span:

• Genome biology of pathological R-loops and their impact on genome stability in cancer and neurodegeneration.
• Cytoplasmic RNA-DNA hybrids and their role in innate immune signalling.
• Extracellular RNA-DNA hybrid release and communication between cells.
• Genomics and computational approaches to study RNA-DNA hybrids in cellular and patient-derived samples.

Why Join Us?

• Exciting science at the intersection of genome stability, immunity and cancer biology.
• Opportunities to develop and apply cutting-edge approaches including long-read sequencing, proteomics, quantitative imaging and functional genomics.
• Strong support for publications, fellowship applications and career development.
• Access to world-class facilities, high-performance computing and specialist training.
• A highly collaborative research environment on the Cambridge Biomedical Campus, alongside Addenbrooke's Hospital, the MRC Laboratory of Molecular Biology, EMBL-EBI and the Wellcome Sanger Institute.

About You You will have:

• A PhD in a relevant discipline (awarded or submitted prior to appointment).
• A strong interest in cancer biology, genome biology, RNA biology, immunology, computational biology or a related field.
• Excellent scientific, communication and collaborative skills.

Whether your background is experimental, computational, or a combination of both, we welcome applications from researchers who are excited to contribute to a rapidly emerging area of biology with significant translational potential.

Find out more about the Crossley Lab: https://www.cruk.cam.ac.uk/research-groups/crossley-group/

Join us and help advance discoveries that could transform our understanding of cancer and other human diseases.

Fixed-term: The funds for this post are available for 2 years in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

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Please quote reference SW51133 on your application and in any correspondence about this vacancy.

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