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Job description

Site Name: UK - Hertfordshire - Ware RD
Posted Date: Mar 24 2020

We are looking for an experienced scientist to join the Biopharmaceutics group within Pharmaceutical Development. This is an exciting opportunity to make a difference to the lives of patients by applying integrated biopharmaceutics to support patient focused product development to help people do more, feel better and live longer. Your role will be to interact with project teams and support the design of all new drug products developed within GSK's Pharmaceutical portfolio. This will be based on biopharmaceutics knowledge created using integrated in-vivo, in-vitro and in-silico (physiologically based pharmacokinetic/biopharmaceutics modelling) tools to design and develop the most suitable drug product that is fit for the patient and meets the development timelines.

Key Responsibilities include, but are not limited to:

  • Applying biopharmaceutics knowledge across projects to support integrated product design, drug delivery and targeting, innovative manufacturing processes, and smart bioavailability and bioequivalency studies, where applicable.
  • Developing projects/platform specific biopharmaceutics knowledge (integrated in-vivo, in-vitro, and in-silico understanding) to support the design and development of exceptional patient focused drug products.
  • Collaborating with partners across MST and IVIVT to build mechanistic understanding of absorption/biopharmaceutics (through use of PBPK modeling, e.g. Gastroplus, Simcyp) and applying this fundamental understanding around product performance, biology and PK to design the best value-added platforms and products.
  • Developing plans for in-vitro biorelevant measurements (e.g. solubility/dissolution, IDR, transfer models) across projects and collaborating with partners (e.g. Materials Science, CMC Analytical) to generate input data for modelling in-vivo product performance.
  • Developing in-vitro and in-silico (digital) models to enable mechanistic, science-based predictions of in-vivo paediatric behaviour of drugs to support paediatric product design.
  • Working with team members in Pharmaceutical Development, Chemical Development, Process Engineering and Analytics and CMC Analytical groups to support development of clinically relevant control strategies (e.g. applying physiologically based biopharmaceutics modeling) across projects for global filings.
  • Providing biopharmaceutics focused technical support as needed to established commercial projects post DG8 when such support is endorsed and prioritized by NPSB.
  • Designing and executing modeling and/or experimental studies that influence project direction in line with QbD approaches.
  • Proactively engaging and collaborating with cross-functional scientists to solve problems. Demonstrating networking skills through interactions across departments and divisions.

Additional responsibilities include:

  • Preparing oral or written summaries of results with interpretation for project work. Writing specific technical sections of internal and external reports. Presenting effectively to internal GSK fora, governance reviews and external meetings.
  • Being responsible for sharing relevant scientific information from internal and external meetings with appropriate colleagues.
  • Demonstrating timely and reliable recording of data/results in suitable systems in accordance with company policy and legal requirements. Performing data management and data stewardship for all work.

Closing Date for Applications: Tuesday 7th April 2020 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:

  • Honours degree or equivalent in an appropriate discipline, with relevant scientific experience and capabilities.
  • Scientific knowledge and successful track record in biopharmaceutics/drug absorption and related tools (in-vivo, in-vitro, in-silico).
  • Experience in mechanistic PBPK modelling (e.g. Gastroplus, Simcyp) and application to product design across dosage forms (e.g. oral, paediatric, long-acting injectable).
  • Experience in in-vitro biorelevant measurements (e.g. solubility/dissolution, IDR, transfer models) for oral biopharmaceutics.
  • Scientific knowledge and understanding of the anatomy/physiology of body, absorption, distribution and metabolism, and integration of biopharmaceutics with formulation design across dosage forms.
  • General knowledge of preclinical and clinical development disciplines including DMPK, Safety, Clinical Pharmacology, etc.
  • Excellent written and oral communication skills and the ability to interact effectively with scientists in other disciplines with a positive and collaborative attitude.
  • Demonstrated collaborative behaviours working in a matrix environment and working across functions / disciplines.

Preferred Qualifications:
If you have the following characteristics, it would be a plus:

  • PhD/Masters in the field of biopharmaceutics, drug absorption/pharmacokinetics, PBPK modeling and/or drug delivery.
  • Demonstrated experience in understanding biopharmaceutics across dosage forms including oral, paediatric, sterile and/or long acting injectable products using QbD principles.
  • Understanding of late-stage product development. Understanding of regulatory requirements for change management for a global file.
  • Demonstrated experience in formulation design across dosage forms.
  • Customer focused, yet challenging.
  • Demonstrated effective interpersonal, communications and negotiation skills.
  • Logical and independent thinking.
  • Managing and delivering execution across multiple disciplines

Why GSK?
Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness

As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email ukdiversity.recruitment@gsk.com

As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

Job Sector
Other
Job Position
Other
City/Town
Ware
Postal Code
SG12
Address
Ware SG12, UK Show on map
Post date
Closing date

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